528.4K XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Uri Weinberg | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 81,499 | 81,499 | - | - | Stock Options (Right to buy) | |
| Uri Weinberg | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 18.19 per share. | 04 Mar 2025 | 54,975 | 221,218 (0%) | 0% | 18.2 | 999,995 | Ordinary Shares |
| Ashley Cordova | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 224,123 | 224,123 | - | - | Stock Options (Right to buy) | |
| Ashley Cordova | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 18.19 per share. | 04 Mar 2025 | 151,181 | 355,186 (0%) | 0% | 18.2 | 2,749,982 | Ordinary Shares |
| Francis Leonard | EVP, Pres., Novocure Oncology | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 81,499 | 81,499 | - | - | Stock Options (Right to buy) | |
| Francis Leonard | EVP, Pres., Novocure Oncology | Grant, award, or other acquisition of securities at price $ 18.19 per share. | 04 Mar 2025 | 54,975 | 198,648 (0%) | 0% | 18.2 | 999,995 | Ordinary Shares |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 81,499 | 81,499 | - | - | Stock Options (Right to buy) | |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 18.19 per share. | 04 Mar 2025 | 54,975 | 173,696 (0%) | 0% | 18.2 | 999,995 | Ordinary Shares |
| Michal Nath Puri | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 18.19 per share. | 04 Mar 2025 | 54,975 | 163,681 (0%) | 0% | 18.2 | 999,995 | Ordinary Shares |
| Michal Nath Puri | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 81,499 | 81,499 | - | - | Stock Options (Right to buy) | |
| Nicholas Leupin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 81,499 | 81,499 | - | - | Stock Options (Right to buy) | |
| Nicholas Leupin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 18.19 per share. | 04 Mar 2025 | 54,975 | 105,108 (0%) | 0% | 18.2 | 999,995 | Ordinary Shares |
| Mukund Paravasthu | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 81,499 | 81,499 | - | - | Stock Options (Right to buy) | |
| Mukund Paravasthu | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 18.19 per share. | 04 Mar 2025 | 54,975 | 84,148 (0%) | 0% | 18.2 | 999,995 | Ordinary Shares |
| Christoph Brackmann | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 18.19 per share. | 04 Mar 2025 | 54,975 | 121,150 (0%) | 0% | 18.2 | 999,995 | Ordinary Shares |
| Christoph Brackmann | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 81,499 | 81,499 | - | - | Stock Options (Right to buy) | |
| Uri Weinberg | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 18.31 per share. | 03 Mar 2025 | 311 | 166,511 (0%) | 0% | 18.3 | 5,695 | Ordinary Shares |
| Uri Weinberg | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 18.78 per share. | 03 Mar 2025 | 4,326 | 166,822 (0%) | 0% | 18.8 | 81,254 | Ordinary Shares |
| Uri Weinberg | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 18.92 per share. | 03 Mar 2025 | 268 | 166,243 (0%) | 0% | 18.9 | 5,071 | Ordinary Shares |
| Ashley Cordova | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 18.54 per share. | 03 Mar 2025 | 2,053 | 204,005 (0%) | 0% | 18.5 | 38,055 | Ordinary Shares |
| Francis Leonard | EVP, Pres., Novocure Oncology | Sale of securities on an exchange or to another person at price $ 18.54 per share. | 03 Mar 2025 | 2,527 | 143,673 (0%) | 0% | 18.5 | 46,841 | Ordinary Shares |
| Mukund Paravasthu | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.54 per share. | 03 Mar 2025 | 250 | 29,173 (0%) | 0% | 18.5 | 4,634 | Ordinary Shares |
| Ashley Cordova | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 20.55 per share. | 27 Feb 2025 | 1,808 | 208,399 (0%) | 0% | 20.5 | 37,153 | Ordinary Shares |
| Ashley Cordova | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 18.28 per share. | 27 Feb 2025 | 2,341 | 206,058 (0%) | 0% | 18.3 | 42,804 | Ordinary Shares |
| Ashley Cordova | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 19.92 per share. | 27 Feb 2025 | 9,345 | 210,207 (0%) | 0% | 19.9 | 186,170 | Ordinary Shares |
| Francis Leonard | EVP, Pres., Novocure Oncology | Sale of securities on an exchange or to another person at price $ 20.55 per share. | 27 Feb 2025 | 1,989 | 148,970 (0%) | 0% | 20.5 | 40,872 | Ordinary Shares |
| Francis Leonard | EVP, Pres., Novocure Oncology | Sale of securities on an exchange or to another person at price $ 18.28 per share. | 27 Feb 2025 | 2,770 | 146,200 (0%) | 0% | 18.3 | 50,648 | Ordinary Shares |
| Francis Leonard | EVP, Pres., Novocure Oncology | Sale of securities on an exchange or to another person at price $ 19.92 per share. | 27 Feb 2025 | 10,277 | 150,959 (0%) | 0% | 19.9 | 204,737 | Ordinary Shares |
| Michal Nath Puri | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 19.92 per share. | 27 Feb 2025 | 1,162 | 108,931 (0%) | 0% | 19.9 | 23,149 | Ordinary Shares |
| Michal Nath Puri | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 20.55 per share. | 27 Feb 2025 | 225 | 108,706 (0%) | 0% | 20.6 | 4,624 | Ordinary Shares |
| Nicholas Leupin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 20.55 per share. | 27 Feb 2025 | 161 | 50,133 (0%) | 0% | 20.5 | 3,308 | Ordinary Shares |
| Nicholas Leupin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 19.92 per share. | 27 Feb 2025 | 830 | 50,294 (0%) | 0% | 19.9 | 16,535 | Ordinary Shares |
| Mukund Paravasthu | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 20.55 per share. | 27 Feb 2025 | 267 | 29,791 (0%) | 0% | 20.6 | 5,487 | Ordinary Shares |
| Mukund Paravasthu | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.92 per share. | 27 Feb 2025 | 1,379 | 30,058 (0%) | 0% | 19.9 | 27,472 | Ordinary Shares |
| Mukund Paravasthu | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.29 per share. | 27 Feb 2025 | 368 | 29,423 (0%) | 0% | 18.3 | 6,729 | Ordinary Shares |
| Mukund Paravasthu | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 26.81 per share. | 11 Jan 2025 | 2,160 | 31,437 (0%) | 0% | 26.8 | 57,906 | Ordinary Shares |
| Asaf Danziger | Director | Grant, award, or other acquisition of securities at price $ 14.75 per share. | 01 Jan 2025 | 412 | 15,640 (0%) | 0% | 14.7 | 6,076 | Ordinary Shares |
| Asaf Danziger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2025 | 400,000 | 415,640 (0%) | 0% | 0 | Ordinary Shares | |
| Ashley Cordova | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 14.75 per share. | 31 Dec 2024 | 373 | 219,552 (0%) | 0% | 14.7 | 5,501 | Ordinary Shares |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 14.75 per share. | 31 Dec 2024 | 669 | 118,721 (0%) | 0% | 14.7 | 9,866 | Ordinary Shares |
| Mukund Paravasthu | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Nov 2024 | 30,138 | 33,597 (0%) | 0% | 0 | Ordinary Shares | |
| Mukund Paravasthu | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Nov 2024 | 45,620 | 45,620 | - | - | Stock Option (Right to Buy) | |
| Mukund Paravasthu | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 16.68 per share. | 02 Nov 2024 | 44 | 3,459 (0%) | 0% | 16.7 | 734 | Ordinary Shares |
| Francis Leonard | EVP, Pres., Novocure Oncology | Sale of securities on an exchange or to another person at price $ 15.94 per share. | 01 Nov 2024 | 598 | 161,236 (0%) | 0% | 15.9 | 9,531 | Ordinary Shares |
| Mukund Paravasthu | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 15.88 per share. | 01 Nov 2024 | 160 | 3,503 (0%) | 0% | 15.9 | 2,540 | Ordinary Shares |
| Michal Nath Puri | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 15.79 per share. | 31 Oct 2024 | 810 | 110,093 (0%) | 0% | 15.8 | 12,792 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.14 per share. | 02 Aug 2024 | 688 | 219,179 (0%) | 0% | 20.1 | 13,857 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 12.24 per share. | 28 Jun 2024 | 1,055 | 252,290 (0%) | 0% | 12.2 | 12,913 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 12.24 per share. | 28 Jun 2024 | 1,239 | 15,228 (0%) | 0% | 12.2 | 15,165 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 12.24 per share. | 28 Jun 2024 | 1,286 | 220,465 (0%) | 0% | 12.2 | 15,741 | Ordinary Shares |
| Francis Leonard | EVP, Pres., Novocure Oncology | Grant, award, or other acquisition of securities at price $ 12.24 per share. | 28 Jun 2024 | 1,736 | 161,834 (0%) | 0% | 12.2 | 21,249 | Ordinary Shares |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 12.24 per share. | 28 Jun 2024 | 930 | 118,052 (0%) | 0% | 12.2 | 11,383 | Ordinary Shares |
| Michal Nath Puri | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 12.24 per share. | 28 Jun 2024 | 1,736 | 110,903 (0%) | 0% | 12.2 | 21,249 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2024 | 124,373 | 95,000 | - | - | Stock Options (Right to buy) | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.82 per share. | 05 Jun 2024 | 124,373 | 124,373 (0%) | 0% | 22.8 | 2,838,192 | Ordinary Shares |
| David T. Hung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 6,229 | 6,229 | - | - | Stock Option (Right to Buy) | |
| David T. Hung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 4,053 | 13,194 | - | 0 | Restricted Stock Units | |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 6,229 | 6,229 | - | - | Stock Option (Right to Buy) | |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 4,053 | 6,590 | - | 0 | Restricted Stock Units | |
| Martin J. Madden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 4,053 | 19,673 (0%) | 0% | 0 | Ordinary Shares | |
| Martin J. Madden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 6,229 | 6,229 | - | - | Stock Option (Right to Buy) | |
| Allyson J. Ocean | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 4,053 | 4,053 | - | 0 | Restricted Stock Units | |
| Allyson J. Ocean | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 6,229 | 6,229 | - | - | Stock Options (Right to buy) | |
| Gabriel Leung | Director | Sale of securities on an exchange or to another person at price $ 23.88 per share. | 04 Jun 2024 | 964 | 78,175 (0%) | 0% | 23.9 | 23,025 | Ordinary Shares |
| Gabriel Leung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 6,229 | 6,229 | - | - | Stock Option (Right to Buy) | |
| Gabriel Leung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 4,053 | 83,192 | - | 0 | Restricted Stock Units | |
| Timothy John Scannell | Director | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 04 Jun 2024 | 964 | 2,964 (0%) | 0% | 23.9 | 23,027 | Ordinary Shares |
| Timothy John Scannell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 6,229 | 6,229 | - | - | Stock Option (Right to Buy) | |
| Timothy John Scannell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 4,053 | 7,981 | - | 0 | Restricted Stock Units | |
| W. Anthony Vernon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 6,229 | 6,229 | - | - | Stock Option (Right to Buy) | |
| W. Anthony Vernon | Director | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 04 Jun 2024 | 964 | 164,833 (0%) | 0% | 23.9 | 23,033 | Ordinary Shares |
| W. Anthony Vernon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 4,053 | 169,850 | - | 0 | Restricted Stock Units | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 16.01 per share. | 01 Mar 2024 | 1,217 | 251,235 (0%) | 0% | 16.0 | 19,484 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 16.03 per share. | 01 Mar 2024 | 2,107 | 252,452 (0%) | 0% | 16.0 | 33,769 | Ordinary Shares |
| Frank Leonard | EVP, Pres., Novocure Oncology | Sale of securities on an exchange or to another person at price $ 16.03 per share. | 01 Mar 2024 | 1,679 | 160,938 (0%) | 0% | 16.0 | 26,909 | Ordinary Shares |
| Frank Leonard | EVP, Pres., Novocure Oncology | Sale of securities on an exchange or to another person at price $ 16.01 per share. | 01 Mar 2024 | 840 | 160,098 (0%) | 0% | 16.0 | 13,448 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 16.14 per share. | 27 Feb 2024 | 2,303 | 254,559 (0%) | 0% | 16.1 | 37,177 | Ordinary Shares |
| Leupin Nicholas | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 16.30 per share. | 27 Feb 2024 | 51,124 | 51,124 (0%) | 0% | 16.3 | 833,321 | Ordinary Shares |
| Uri Weinberg | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 16.30 per share. | 27 Feb 2024 | 81,799 | 171,148 (0%) | 0% | 16.3 | 1,333,324 | Ordinary Shares |
| Barak Arye Ben | General Counsel | Grant, award, or other acquisition of securities at price $ 16.30 per share. | 27 Feb 2024 | 81,799 | 117,122 (0%) | 0% | 16.3 | 1,333,324 | Ordinary Shares |
| Giladi Moshe | Chief Science Officer | 27 Feb 2024 | 51,124 | 69,771 (0%) | 0% | 16.3 | 833,321 | Ordinary Shares | |
| Ben Arye Barak | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 125,078 | 125,078 | - | - | Stock Options (Right to buy) | |
| Nicholas Leupin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 78,174 | 78,174 | - | - | Stock Options (Right to buy) | |
| Michal Nath Puri | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 109,443 | 109,443 | - | - | Stock Options (Right to buy) | |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 156,348 | 156,348 | - | - | Stock Options (Right to buy) | |
| Groenhuysen C. M. Wilhelmus | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 71,920 | 71,920 | - | - | Stock Options (Right to buy) | |
| C. M. Wilhelmus Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 16.30 per share. | 27 Feb 2024 | 47,034 | 256,862 (0%) | 0% | 16.3 | 766,654 | Ordinary Shares |
| Arye Barak Ben | General Counsel | Grant, award, or other acquisition of securities at price $ 12.69 per share. | 27 Feb 2024 | 128 | 35,323 (0%) | 0% | 12.7 | 1,624 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 16.30 per share. | 27 Feb 2024 | 102,249 | 219,867 (0%) | 0% | 16.3 | 1,666,659 | Ordinary Shares |
| Frank Leonard | EVP, Pres., Novocure Oncology | Grant, award, or other acquisition of securities at price $ 16.30 per share. | 27 Feb 2024 | 102,249 | 164,695 (0%) | 0% | 16.3 | 1,666,659 | Ordinary Shares |
| Nath Michal Puri | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 16.30 per share. | 27 Feb 2024 | 71,574 | 109,167 (0%) | 0% | 16.3 | 1,166,656 | Ordinary Shares |
| Weinberg Uri | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 125,078 | 125,078 | - | - | Stock Options (Right to buy) | |
| Wilhelmus Groenhuysen C. M. | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 12.67 per share. | 27 Feb 2024 | 3 | 209,828 (0%) | 0% | 12.7 | 38 | Ordinary Shares |
| Giladi Moshe | Chief Science Officer | 27 Feb 2024 | 78,174 | 78,174 | - | - | Stock Options (Right to buy) | ||
| Frank Leonard | EVP, Pres., Novocure Oncology | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 156,348 | 156,348 | - | - | Stock Options (Right to buy) | |
| Leonard Frank | EVP, Pres., Novocure Oncology | Sale of securities on an exchange or to another person at price $ 16.14 per share. | 27 Feb 2024 | 2,078 | 162,617 (0%) | 0% | 16.1 | 33,545 | Ordinary Shares |
| Pritesh Shah | Chief Growth Officer | Sale of securities on an exchange or to another person at price $ 12.65 per share. | 07 Nov 2023 | 382 | 124,511 (0%) | 0% | 12.6 | 4,832 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.46 per share. | 31 Oct 2023 | 7,561 | 107,211 (0%) | 0% | 11.5 | 86,649 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.44 per share. | 31 Oct 2023 | 2,480 | 109,691 (0%) | 0% | 11.4 | 28,371 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.15 per share. | 31 Oct 2023 | 7,752 | 117,443 (0%) | 0% | 7.2 | 55,427 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2023 | 7,561 | 175 | - | - | Stock Option (Right to Buy) | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.46 per share. | 31 Oct 2023 | 175 | 117,618 (0%) | 0% | 11.5 | 2,006 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2023 | 175 | 0 | - | - | Stock Option (Right to Buy) | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2023 | 7,752 | 0 | - | - | Stock Option (Right to Buy) | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2023 | 2,480 | 0 | - | - | Stock Option (Right to Buy) | |
| Michal Nath Puri | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Oct 2023 | 57,604 | 57,604 | - | - | Stock Option (Right to Buy) | |
| Michal Nath Puri | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Oct 2023 | 37,593 | 37,593 (0%) | 0% | 0 | Ordinary Shares | |
| Pritesh Shah | Chief Growth Officer | Sale of securities on an exchange or to another person at price $ 21.82 per share. | 01 Sep 2023 | 273 | 124,893 (0%) | 0% | 21.8 | 5,956 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 21.82 per share. | 01 Sep 2023 | 294 | 209,825 (0%) | 0% | 21.8 | 6,414 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.82 per share. | 01 Sep 2023 | 883 | 99,650 (0%) | 0% | 21.8 | 19,265 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.25 per share. | 02 Aug 2023 | 1,144 | 100,533 (0%) | 0% | 30.3 | 34,607 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 35.28 per share. | 30 Jun 2023 | 366 | 210,119 (0%) | 0% | 35.3 | 12,912 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 35.28 per share. | 30 Jun 2023 | 367 | 13,989 (0%) | 0% | 35.3 | 12,948 | Ordinary Shares |
| Pritesh Shah | Chief Growth Officer | Grant, award, or other acquisition of securities at price $ 35.28 per share. | 30 Jun 2023 | 367 | 125,166 (0%) | 0% | 35.3 | 12,948 | Ordinary Shares |
| Uri Weinberg | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 35.28 per share. | 30 Jun 2023 | 305 | 89,349 (0%) | 0% | 35.3 | 10,760 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 35.28 per share. | 30 Jun 2023 | 367 | 101,677 (0%) | 0% | 35.3 | 12,948 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 35.28 per share. | 30 Jun 2023 | 357 | 66,447 (0%) | 0% | 35.3 | 12,595 | Ordinary Shares |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 35.28 per share. | 30 Jun 2023 | 288 | 35,195 (0%) | 0% | 35.3 | 10,161 | Ordinary Shares |
| Gabriel Leung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,853 | 79,139 | - | 0 | Restricted Stock Units | |
| Gabriel Leung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 6,277 | 6,277 | - | - | Stock Option (Right to Buy) | |
| Timothy John Scannell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 6,277 | 6,277 | - | - | Stock Option (Right to Buy) | |
| Timothy John Scannell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,853 | 3,928 | - | 0 | Restricted Stock Units | |
| David T. Hung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 12,554 | 12,554 | - | - | Stock Option (Right to Buy) | |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 12,554 | 12,554 | - | - | Stock Option (Right to Buy) | |
| W. Anthony Vernon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 6,277 | 6,277 | - | - | Stock Option (Right to Buy) | |
| W. Anthony Vernon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,853 | 165,797 | - | 0 | Restricted Stock Units | |
| Martin J. Madden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 12,554 | 12,554 | - | - | Stock Option (Right to Buy) | |
| Kristin Stafford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2023 | 6,229 | 6,229 | - | - | Stock Option (Right to Buy) | |
| Kristin Stafford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2023 | 4,053 | 4,053 (0%) | 0% | 0 | Ordinary Shares | |
| Kristin Stafford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2023 | 15,873 | 15,873 | - | - | Stock Option (Right to Buy) | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 1,692 | 230,168 (0%) | 0% | 76.2 | 128,862 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 3,528 | 231,860 (0%) | 0% | 76.2 | 268,690 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 20,415 | 209,753 (0%) | 0% | 76.2 | 1,554,794 | Ordinary Shares |
| Pritesh Shah | Chief Growth Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 1,570 | 144,650 (0%) | 0% | 76.2 | 119,570 | Ordinary Shares |
| Pritesh Shah | Chief Growth Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 16,909 | 124,799 (0%) | 0% | 76.2 | 1,287,779 | Ordinary Shares |
| Pritesh Shah | Chief Growth Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 2,942 | 141,708 (0%) | 0% | 76.2 | 224,061 | Ordinary Shares |
| Uri Weinberg | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 3,936 | 89,044 (0%) | 0% | 0 | Ordinary Shares | |
| Uri Weinberg | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 28,830 | 85,108 (0%) | 0% | 0 | Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 4,730 | 102,085 (0%) | 0% | 76.2 | 360,234 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 775 | 101,310 (0%) | 0% | 76.2 | 59,024 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 4,403 | 63,490 (0%) | 0% | 76.2 | 335,330 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 75.59 per share. | 03 Mar 2023 | 2,315 | 54,284 (0%) | 0% | 75.6 | 174,999 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 888 | 62,602 (0%) | 0% | 76.2 | 67,630 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 75.00 per share. | 03 Mar 2023 | 6,003 | 56,599 (0%) | 0% | 75.0 | 450,206 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 76.16 per share. | 03 Mar 2023 | 593 | 66,090 (0%) | 0% | 76.2 | 45,163 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 48,050 | 231,452 (0%) | 0% | 0 | Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 3,936 | 235,388 (0%) | 0% | 0 | Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 75.28 per share. | 02 Mar 2023 | 1,213 | 183,402 (0%) | 0% | 75.3 | 91,312 | Ordinary Shares |
| Pritesh Shah | Chief Growth Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 43,246 | 146,220 (0%) | 0% | 0 | Ordinary Shares | |
| Pritesh Shah | Chief Growth Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 3,936 | 102,974 (0%) | 0% | 0 | Ordinary Shares | |
| Pritesh Shah | Chief Growth Officer | Sale of securities on an exchange or to another person at price $ 75.28 per share. | 02 Mar 2023 | 937 | 99,038 (0%) | 0% | 75.3 | 70,535 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 75.28 per share. | 02 Mar 2023 | 1,055 | 95,007 (0%) | 0% | 75.3 | 79,418 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 11,808 | 106,815 (0%) | 0% | 0 | Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 75.32 per share. | 02 Mar 2023 | 3,799 | 59,296 (0%) | 0% | 75.3 | 286,154 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 77.64 per share. | 02 Mar 2023 | 2,059 | 67,893 (0%) | 0% | 77.6 | 159,859 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 11,808 | 69,952 (0%) | 0% | 0 | Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 75.28 per share. | 02 Mar 2023 | 844 | 58,144 (0%) | 0% | 75.3 | 63,535 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 76.05 per share. | 02 Mar 2023 | 308 | 58,988 (0%) | 0% | 76.1 | 23,424 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 75.28 per share. | 02 Mar 2023 | 281 | 66,683 (0%) | 0% | 75.3 | 21,153 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 76.36 per share. | 28 Feb 2023 | 2,164 | 184,615 (0%) | 0% | 76.4 | 165,248 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 21,653 | 186,779 (0%) | 0% | 0 | Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 36,013 | 36,013 | - | - | Options to Buy Ordinary Shares | |
| Pritesh Shah | Chief Growth Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 31,691 | 31,691 | - | - | Options to Buy Ordinary Shares | |
| Pritesh Shah | Chief Growth Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 19,055 | 101,898 (0%) | 0% | 0 | Ordinary Shares | |
| Pritesh Shah | Chief Growth Officer | Sale of securities on an exchange or to another person at price $ 76.36 per share. | 28 Feb 2023 | 1,923 | 99,975 (0%) | 0% | 76.4 | 146,845 | Ordinary Shares |
| Uri Weinberg | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 21,607 | 21,607 | - | - | Options to Buy Ordinary Shares | |
| Uri Weinberg | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 12,992 | 56,278 (0%) | 0% | 0 | Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 23,818 | 98,260 (0%) | 0% | 0 | Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 39,614 | 39,614 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 76.36 per share. | 28 Feb 2023 | 2,198 | 96,062 (0%) | 0% | 76.4 | 167,845 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 76.36 per share. | 28 Feb 2023 | 1,684 | 63,095 (0%) | 0% | 76.4 | 128,594 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 18,621 | 64,779 (0%) | 0% | 0 | Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 30,971 | 30,971 | - | - | Options to Buy Ordinary Shares | |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 12,125 | 67,719 (0%) | 0% | 0 | Ordinary Shares | |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 76.36 per share. | 28 Feb 2023 | 755 | 66,964 (0%) | 0% | 76.4 | 57,654 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 20,168 | 20,168 | - | - | Options to Buy Ordinary Shares | |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 17,755 | 34,907 (0%) | 0% | 0 | Ordinary Shares | |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 29,531 | 29,531 | - | - | Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 62.30 per share. | 06 Jan 2023 | 102 | 165,126 (0%) | 0% | 62.3 | 6,355 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 62.31 per share. | 06 Jan 2023 | 98 | 28,770 (0%) | 0% | 62.3 | 6,106 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 62.30 per share. | 06 Jan 2023 | 66 | 74,442 (0%) | 0% | 62.3 | 4,112 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 62.31 per share. | 06 Jan 2023 | 108 | 55,594 (0%) | 0% | 62.3 | 6,729 | Ordinary Shares |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 62.31 per share. | 06 Jan 2023 | 150 | 17,152 (0%) | 0% | 62.3 | 9,346 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 119.99 per share. | 05 Jan 2023 | 500 | 13,583 (0%) | 0% | 120.0 | 59,994 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 108.00 per share. | 05 Jan 2023 | 187,500 | 13,583 (0%) | 0% | 108 | 20,250,000 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 62.31 per share. | 05 Jan 2023 | 39 | 13,622 (0%) | 0% | 62.3 | 2,430 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 25,000 | 0 | - | - | Options to Buy Ordinary Shares | |
| Asaf Danziger | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 187,500 | 0 | - | - | Options to Buy Ordinary Shares | |
| Asaf Danziger | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.15 per share. | 05 Jan 2023 | 187,500 | 201,083 (0%) | 0% | 7.2 | 1,340,625 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 112.86 per share. | 05 Jan 2023 | 2,000 | 28,214 (0%) | 0% | 112.9 | 225,726 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 111.23 per share. | 05 Jan 2023 | 8,369 | 30,214 (0%) | 0% | 111.2 | 930,916 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 114.35 per share. | 05 Jan 2023 | 4,568 | 23,646 (0%) | 0% | 114.4 | 522,362 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 115.21 per share. | 05 Jan 2023 | 3,702 | 19,944 (0%) | 0% | 115.2 | 426,512 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 116.06 per share. | 05 Jan 2023 | 1,395 | 18,549 (0%) | 0% | 116.1 | 161,906 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 117.01 per share. | 05 Jan 2023 | 999 | 17,550 (0%) | 0% | 117.0 | 116,894 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 118.47 per share. | 05 Jan 2023 | 2,123 | 15,427 (0%) | 0% | 118.5 | 251,515 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.46 per share. | 05 Jan 2023 | 25,000 | 38,583 (0%) | 0% | 11.5 | 286,500 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 119.35 per share. | 05 Jan 2023 | 1,344 | 14,083 (0%) | 0% | 119.3 | 160,405 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 108.00 per share. | 05 Jan 2023 | 387 | 82,843 (0%) | 0% | 108 | 41,796 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Sale of securities on an exchange or to another person at price $ 120.00 per share. | 05 Jan 2023 | 2,379 | 47,104 (0%) | 0% | 120 | 285,480 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 1,946 | 1,946 | - | - | Options to Buy Ordinary Shares | |
| Uri Weinberg | Chief Science Officer | Sale of securities on an exchange or to another person at price $ 120.00 per share. | 05 Jan 2023 | 1,201 | 43,286 (0%) | 0% | 120 | 144,120 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Sale of securities on an exchange or to another person at price $ 108.00 per share. | 05 Jan 2023 | 2,617 | 44,487 (0%) | 0% | 108 | 282,636 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Sale of securities on an exchange or to another person at price $ 120.00 per share. | 05 Jan 2023 | 1,946 | 47,104 (0%) | 0% | 120 | 233,520 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.04 per share. | 05 Jan 2023 | 1,946 | 49,050 (0%) | 0% | 47.0 | 91,540 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 115.03 per share. | 05 Jan 2023 | 526 | 47,168 (0%) | 0% | 115.0 | 60,508 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 108.00 per share. | 05 Jan 2023 | 417 | 47,694 (0%) | 0% | 108 | 45,036 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 119.01 per share. | 05 Jan 2023 | 2,345 | 48,111 (0%) | 0% | 119.0 | 279,073 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 117.00 per share. | 05 Jan 2023 | 1,010 | 46,158 (0%) | 0% | 117 | 118,170 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.37 per share. | 05 Jan 2023 | 7,826 | 53,984 (0%) | 0% | 14.4 | 112,460 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 108.00 per share. | 05 Jan 2023 | 7,826 | 46,158 (0%) | 0% | 108 | 845,208 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.46 per share. | 05 Jan 2023 | 7,500 | 53,658 (0%) | 0% | 11.5 | 85,950 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 108.00 per share. | 05 Jan 2023 | 7,500 | 46,158 (0%) | 0% | 108 | 810,000 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.15 per share. | 05 Jan 2023 | 5,517 | 51,675 (0%) | 0% | 7.2 | 39,447 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 108.00 per share. | 05 Jan 2023 | 5,517 | 46,158 (0%) | 0% | 108 | 595,836 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.15 per share. | 05 Jan 2023 | 7,183 | 53,341 (0%) | 0% | 21.1 | 151,920 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 114.00 per share. | 05 Jan 2023 | 7,183 | 46,158 (0%) | 0% | 114.0 | 818,863 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.15 per share. | 05 Jan 2023 | 7,183 | 53,341 (0%) | 0% | 21.1 | 151,920 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 120.00 per share. | 05 Jan 2023 | 7,183 | 46,158 (0%) | 0% | 120 | 861,960 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 7,826 | 0 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 7,500 | 0 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 5,517 | 0 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 7,183 | 10,479 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 7,183 | 17,662 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2022 | 2,000 | 7,752 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.15 per share. | 02 Dec 2022 | 2,000 | 74,376 (0%) | 0% | 7.2 | 14,300 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2022 | 11,609 | 11,609 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2022 | 6,830 | 50,456 (0%) | 0% | 0 | Ordinary Shares | |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 76.01 per share. | 13 Oct 2022 | 6,754 | 43,626 (0%) | 0% | 76.0 | 513,372 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 84.37 per share. | 06 Oct 2022 | 6,754 | 50,380 (0%) | 0% | 84.4 | 569,835 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 77.35 per share. | 29 Sep 2022 | 6,754 | 57,134 (0%) | 0% | 77.4 | 522,422 | Ordinary Shares |
| Frank Leonard | President, CNS Cancers US | Sale of securities on an exchange or to another person at price $ 77.00 per share. | 22 Sep 2022 | 6,754 | 63,888 (0%) | 0% | 77 | 520,058 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.15 per share. | 15 Sep 2022 | 5,517 | 82,913 (0%) | 0% | 7.2 | 39,447 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2022 | 5,517 | 5,517 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 15 Sep 2022 | 5,517 | 70,642 (0%) | 0% | 90 | 496,530 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 87.31 per share. | 15 Sep 2022 | 6,754 | 76,159 (0%) | 0% | 87.3 | 589,692 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 81.48 per share. | 08 Sep 2022 | 6,754 | 77,396 (0%) | 0% | 81.5 | 550,316 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.57 per share. | 06 Sep 2022 | 1,384 | 86,013 (0%) | 0% | 78.6 | 108,741 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 79.04 per share. | 02 Sep 2022 | 296 | 165,024 (0%) | 0% | 79.0 | 23,395 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 79.04 per share. | 02 Sep 2022 | 269 | 83,230 (0%) | 0% | 79.0 | 21,261 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 79.04 per share. | 02 Sep 2022 | 885 | 72,376 (0%) | 0% | 79.0 | 69,948 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 79.04 per share. | 02 Sep 2022 | 718 | 55,486 (0%) | 0% | 79.0 | 56,749 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 77.06 per share. | 01 Sep 2022 | 360 | 88,467 (0%) | 0% | 77.1 | 27,742 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 79.04 per share. | 01 Sep 2022 | 584 | 87,397 (0%) | 0% | 79.0 | 46,158 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.96 per share. | 01 Sep 2022 | 48 | 87,981 (0%) | 0% | 79.0 | 3,790 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.14 per share. | 01 Sep 2022 | 438 | 88,029 (0%) | 0% | 78.1 | 34,225 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.88 per share. | 01 Sep 2022 | 240 | 88,827 (0%) | 0% | 75.9 | 18,210 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.68 per share. | 01 Sep 2022 | 1,088 | 89,067 (0%) | 0% | 78.7 | 85,602 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 77.92 per share. | 01 Sep 2022 | 2,720 | 90,155 (0%) | 0% | 77.9 | 211,934 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 76.96 per share. | 01 Sep 2022 | 1,750 | 92,875 (0%) | 0% | 77.0 | 134,677 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.93 per share. | 01 Sep 2022 | 1,200 | 94,625 (0%) | 0% | 75.9 | 91,114 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.66 per share. | 01 Sep 2022 | 452 | 95,825 (0%) | 0% | 78.7 | 35,556 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.08 per share. | 01 Sep 2022 | 2,955 | 96,277 (0%) | 0% | 78.1 | 230,741 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 77.00 per share. | 01 Sep 2022 | 1,914 | 99,232 (0%) | 0% | 77.0 | 147,382 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 75.94 per share. | 01 Sep 2022 | 1,047 | 101,146 (0%) | 0% | 75.9 | 79,504 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 74.00 per share. | 03 Aug 2022 | 5,396 | 28,672 (0%) | 0% | 74 | 399,304 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 71.09 per share. | 03 Aug 2022 | 563 | 34,068 (0%) | 0% | 71.1 | 40,024 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 69.66 per share. | 02 Aug 2022 | 837 | 551,176 (0%) | 0% | 69.7 | 58,305 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 69.66 per share. | 02 Aug 2022 | 437 | 34,631 (0%) | 0% | 69.7 | 30,441 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 70.20 per share. | 02 Aug 2022 | 7,122 | 73,261 (0%) | 0% | 70.2 | 499,964 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 69.66 per share. | 02 Aug 2022 | 414 | 102,193 (0%) | 0% | 69.7 | 28,839 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 59.07 per share. | 05 Jul 2022 | 218 | 165,320 (0%) | 0% | 59.1 | 12,878 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 59.08 per share. | 05 Jul 2022 | 222 | 35,068 (0%) | 0% | 59.1 | 13,115 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 59.08 per share. | 05 Jul 2022 | 276 | 13,583 (0%) | 0% | 59.1 | 16,305 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 59.07 per share. | 05 Jul 2022 | 312 | 83,499 (0%) | 0% | 59.1 | 18,431 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Grant, award, or other acquisition of securities at price $ 59.07 per share. | 05 Jul 2022 | 281 | 49,483 (0%) | 0% | 59.1 | 16,600 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 59.08 per share. | 05 Jul 2022 | 251 | 66,139 (0%) | 0% | 59.1 | 14,828 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 59.07 per share. | 05 Jul 2022 | 312 | 102,607 (0%) | 0% | 59.1 | 18,431 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 59.08 per share. | 05 Jul 2022 | 213 | 56,204 (0%) | 0% | 59.1 | 12,583 | Ordinary Shares |
| Barak Ben Arye | General Counsel | Grant, award, or other acquisition of securities at price $ 59.08 per share. | 05 Jul 2022 | 144 | 17,002 (0%) | 0% | 59.1 | 8,507 | Ordinary Shares |
| Jeryl L. Hilleman | Director | Sale of securities on an exchange or to another person at price $ 69.61 per share. | 10 Jun 2022 | 407 | 2,537 (0%) | 0% | 69.6 | 28,331 | Ordinary Shares |
| Gabriel Leung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 4,350 | 4,350 | - | - | Options to Buy Ordinary Shares | |
| Gabriel Leung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 2,427 | 75,286 | - | 0 | Restricted Stock Units | |
| Timothy John Scannell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 8,700 | 8,700 | - | - | Options to Buy Ordinary Shares | |
| David T. Hung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 4,350 | 4,350 | - | - | Options to Buy Ordinary Shares | |
| David T. Hung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 2,427 | 9,141 | - | 0 | Restricted Stock Units | |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 8,700 | 8,700 | - | - | Options to Buy Ordinary Shares | |
| W. Anthony Vernon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 8,700 | 8,700 | - | - | Options to Buy Ordinary Shares | |
| Martin J. Madden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 8,700 | 8,700 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 65.16 per share. | 10 May 2022 | 2,070 | 36,981 (0%) | 0% | 65.2 | 134,877 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 61.25 per share. | 10 May 2022 | 2,135 | 34,846 (0%) | 0% | 61.3 | 130,769 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 05 May 2022 | 1,324 | 147,048 | - | - | Options to Buy Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 05 May 2022 | 1,324 | 0 | - | - | Options to Buy Ordinary Shares | |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 70.10 per share. | 08 Mar 2022 | 2,385 | 552,013 (0%) | 0% | 70.1 | 167,189 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 70.10 per share. | 08 Mar 2022 | 2,923 | 165,102 (0%) | 0% | 70.1 | 204,902 | Ordinary Shares |
| Todd Christopher Longsworth | General Counsel | Sale of securities on an exchange or to another person at price $ 70.10 per share. | 08 Mar 2022 | 2,339 | 62,462 (0%) | 0% | 70.1 | 163,964 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 70.10 per share. | 08 Mar 2022 | 759 | 60,848 (0%) | 0% | 70.1 | 53,206 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 70.10 per share. | 08 Mar 2022 | 744 | 102,295 (0%) | 0% | 70.1 | 52,154 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 70.10 per share. | 08 Mar 2022 | 1,037 | 55,991 (0%) | 0% | 70.1 | 72,694 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 70.10 per share. | 07 Mar 2022 | 2,481 | 81,908 (0%) | 0% | 70.1 | 173,918 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 69.55 per share. | 07 Mar 2022 | 5,294 | 84,389 (0%) | 0% | 69.6 | 368,198 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 14,581 | 14,581 | - | - | Options to Buy Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 74.50 per share. | 03 Mar 2022 | 1,301 | 170,594 (0%) | 0% | 74.5 | 96,922 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 7,664 | 7,664 | - | - | Options to Buy Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 38,390 | 38,390 | - | - | Options to Buy Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 70.41 per share. | 03 Mar 2022 | 2,569 | 168,025 (0%) | 0% | 70.4 | 180,876 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 21,921 | 171,895 (0%) | 0% | 0 | Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 5,452 | 5,452 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 17,371 | 45,570 (0%) | 0% | 0 | Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 74.50 per share. | 03 Mar 2022 | 803 | 44,767 (0%) | 0% | 74.5 | 59,822 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 70.41 per share. | 03 Mar 2022 | 1,510 | 43,257 (0%) | 0% | 70.4 | 106,315 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 30,422 | 30,422 | - | - | Options to Buy Ordinary Shares | |
| Asaf Danziger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 13,470 | 13,470 | - | - | Options to Buy Ordinary Shares | |
| Todd Christopher Longsworth | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 6,106 | 6,106 | - | - | Options to Buy Ordinary Shares | |
| Todd Christopher Longsworth | General Counsel | Sale of securities on an exchange or to another person at price $ 70.41 per share. | 03 Mar 2022 | 1,973 | 64,801 (0%) | 0% | 70.4 | 138,913 | Ordinary Shares |
| Todd Christopher Longsworth | General Counsel | Sale of securities on an exchange or to another person at price $ 74.50 per share. | 03 Mar 2022 | 1,094 | 66,774 (0%) | 0% | 74.5 | 81,501 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 73.34 per share. | 03 Mar 2022 | 2,632 | 91,597 (0%) | 0% | 73.3 | 193,031 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 74.50 per share. | 03 Mar 2022 | 997 | 94,229 (0%) | 0% | 74.5 | 74,275 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 6,231 | 6,231 | - | - | Options to Buy Ordinary Shares | |
| Pritesh Shah | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 38,027 | 38,027 | - | - | Options to Buy Ordinary Shares | |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 70.41 per share. | 03 Mar 2022 | 1,914 | 89,683 (0%) | 0% | 70.4 | 134,759 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 21,714 | 95,226 (0%) | 0% | 0 | Ordinary Shares | |
| Uri Weinberg | Chief Science Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 30,422 | 30,422 | - | - | Options to Buy Ordinary Shares | |
| Uri Weinberg | Chief Science Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 4,961 | 4,961 | - | - | Options to Buy Ordinary Shares | |
| Uri Weinberg | Chief Science Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 17,371 | 49,186 (0%) | 0% | 0 | Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2022 | 1,200 | 7,736 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 5,140 | 5,140 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 37,664 | 37,664 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 70.41 per share. | 03 Mar 2022 | 556 | 61,607 (0%) | 0% | 70.4 | 39,146 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 74.50 per share. | 03 Mar 2022 | 1,149 | 62,163 (0%) | 0% | 74.5 | 85,598 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 21,508 | 63,312 (0%) | 0% | 0 | Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.60 per share. | 03 Mar 2022 | 3,840 | 64,688 (0%) | 0% | 15.6 | 59,904 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.46 per share. | 03 Mar 2022 | 1,200 | 65,888 (0%) | 0% | 11.5 | 13,752 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2022 | 3,840 | 0 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 30,422 | 30,422 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 4,933 | 4,933 | - | - | Options to Buy Ordinary Shares | |
| Frank Leonard | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 17,371 | 104,524 (0%) | 0% | 0 | Ordinary Shares | |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 74.50 per share. | 03 Mar 2022 | 930 | 103,594 (0%) | 0% | 74.5 | 69,283 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 70.41 per share. | 03 Mar 2022 | 555 | 103,039 (0%) | 0% | 70.4 | 39,076 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 7,445 | 58,395 (0%) | 0% | 0 | Ordinary Shares | |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 4,361 | 4,361 | - | - | Options to Buy Ordinary Shares | |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 13,038 | 13,038 | - | - | Options to Buy Ordinary Shares | |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 70.41 per share. | 03 Mar 2022 | 1,026 | 57,028 (0%) | 0% | 70.4 | 72,238 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 74.50 per share. | 03 Mar 2022 | 341 | 58,054 (0%) | 0% | 74.5 | 25,404 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 63.81 per share. | 06 Jan 2022 | 75 | 149,974 (0%) | 0% | 63.8 | 4,786 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 63.82 per share. | 06 Jan 2022 | 55 | 28,199 (0%) | 0% | 63.8 | 3,510 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 63.81 per share. | 06 Jan 2022 | 31 | 13,307 (0%) | 0% | 63.8 | 1,978 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Grant, award, or other acquisition of securities at price $ 63.83 per share. | 06 Jan 2022 | 35 | 31,815 (0%) | 0% | 63.8 | 2,234 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 63.83 per share. | 06 Jan 2022 | 46 | 41,804 (0%) | 0% | 63.8 | 2,936 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 63.81 per share. | 06 Jan 2022 | 80 | 50,950 (0%) | 0% | 63.8 | 5,105 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 75.96 per share. | 03 Jan 2022 | 2,633 | 41,036 (0%) | 0% | 76.0 | 200,003 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.15 per share. | 03 Jan 2022 | 9,750 | 50,786 (0%) | 0% | 7.2 | 69,713 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.60 per share. | 03 Jan 2022 | 1,402 | 51,269 (0%) | 0% | 21.6 | 30,283 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 76.09 per share. | 03 Jan 2022 | 919 | 49,867 (0%) | 0% | 76.1 | 69,924 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Sale of securities on an exchange or to another person at price $ 76.03 per share. | 03 Jan 2022 | 399 | 50,870 (0%) | 0% | 76.0 | 30,336 | Ordinary Shares |
| William Patrick Burke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 17,452 | 0 | - | - | Options to Buy Ordinary Shares | |
| William Patrick Burke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 1,402 | 6,098 | - | - | Options to Buy Ordinary Shares | |
| William Patrick Burke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 9,750 | 0 | - | - | Options to Buy Ordinary Shares | |
| William Patrick Burke | Chief Human Resources Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.46 per share. | 03 Jan 2022 | 17,452 | 43,669 (0%) | 0% | 11.5 | 200,000 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 103.37 per share. | 26 Nov 2021 | 1,000 | 13,172 (0%) | 0% | 103.4 | 103,370 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 96.50 per share. | 26 Nov 2021 | 104 | 13,276 (0%) | 0% | 96.5 | 10,036 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 102.36 per share. | 26 Nov 2021 | 3,870 | 12,172 (0%) | 0% | 102.4 | 396,133 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 107.28 per share. | 02 Nov 2021 | 209 | 41,758 (0%) | 0% | 107.3 | 22,421 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 138.23 per share. | 02 Sep 2021 | 181 | 149,899 (0%) | 0% | 138.2 | 25,020 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 139.24 per share. | 02 Sep 2021 | 150 | 73,542 (0%) | 0% | 139.2 | 20,886 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 140.17 per share. | 02 Sep 2021 | 30 | 73,512 (0%) | 0% | 140.2 | 4,205 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 138.27 per share. | 02 Sep 2021 | 321 | 73,692 (0%) | 0% | 138.3 | 44,386 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 138.23 per share. | 02 Sep 2021 | 156 | 74,013 (0%) | 0% | 138.2 | 21,564 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 138.23 per share. | 02 Sep 2021 | 828 | 41,967 (0%) | 0% | 138.2 | 114,456 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 138.23 per share. | 02 Sep 2021 | 540 | 87,153 (0%) | 0% | 138.2 | 74,645 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.50 per share. | 12 Aug 2021 | 8,026 | 54,019 (0%) | 0% | 21.5 | 172,559 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2021 | 2,606 | 6,375 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2021 | 7,298 | 5,172 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2021 | 2,767 | 5,533 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2021 | 8,026 | 3,297 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2021 | 5,927 | 0 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2021 | 10,000 | 3,840 | - | - | Options to Buy Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Aug 2021 | 1,733 | 44,260 (0%) | 0% | 0 | Ordinary Shares | |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 140.90 per share. | 12 Aug 2021 | 2,606 | 45,993 (0%) | 0% | 140.9 | 367,185 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 69.37 per share. | 12 Aug 2021 | 2,606 | 48,599 (0%) | 0% | 69.4 | 180,778 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 140.90 per share. | 12 Aug 2021 | 7,298 | 45,993 (0%) | 0% | 140.9 | 1,028,288 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.04 per share. | 12 Aug 2021 | 7,298 | 53,291 (0%) | 0% | 47.0 | 343,298 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 140.90 per share. | 12 Aug 2021 | 2,767 | 45,993 (0%) | 0% | 140.9 | 389,870 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.02 per share. | 12 Aug 2021 | 2,767 | 48,760 (0%) | 0% | 32.0 | 88,599 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 140.90 per share. | 12 Aug 2021 | 8,026 | 45,993 (0%) | 0% | 140.9 | 1,130,879 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 141.06 per share. | 12 Aug 2021 | 5,927 | 45,993 (0%) | 0% | 141.1 | 836,063 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.25 per share. | 12 Aug 2021 | 5,927 | 51,920 (0%) | 0% | 19.3 | 114,095 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.60 per share. | 12 Aug 2021 | 10,000 | 45,993 (0%) | 0% | 15.6 | 156,000 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Aug 2021 | 320 | 145,724 | - | - | Options to Buy Ordinary Shares | |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Aug 2021 | 320 | 1,324 | - | - | Options to Buy Ordinary Shares | |
| Gabriel Leung | Director | Sale of securities on an exchange or to another person at price $ 152.50 per share. | 05 Aug 2021 | 1,000 | 72,859 (0%) | 0% | 152.5 | 152,500 | Ordinary Shares |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2021 | 1,000 | 2,345 | - | - | Options to Buy Ordinary Shares | |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.45 per share. | 05 Aug 2021 | 1,000 | 73,859 (0%) | 0% | 31.5 | 31,450 | Ordinary Shares |
| Martin J. Madden | Director | Sale of securities on an exchange or to another person at price $ 153.12 per share. | 05 Aug 2021 | 34 | 384 (0%) | 0% | 153.1 | 5,206 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 148.71 per share. | 04 Aug 2021 | 2,063 | 74,169 (0%) | 0% | 148.7 | 306,789 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 150.11 per share. | 03 Aug 2021 | 464 | 28,144 (0%) | 0% | 150.1 | 69,651 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 149.43 per share. | 03 Aug 2021 | 1,654 | 76,232 (0%) | 0% | 149.4 | 247,157 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 149.38 per share. | 02 Aug 2021 | 995 | 554,398 (0%) | 0% | 149.4 | 148,631 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 149.38 per share. | 02 Aug 2021 | 713 | 89,486 (0%) | 0% | 149.4 | 106,507 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 149.43 per share. | 02 Aug 2021 | 328 | 89,158 (0%) | 0% | 149.4 | 49,013 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 83.30 per share. | 30 Jul 2021 | 651 | 29,795 (0%) | 0% | 83.3 | 54,228 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2021 | 651 | 3,253 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 149.38 per share. | 30 Jul 2021 | 536 | 28,608 (0%) | 0% | 149.4 | 80,067 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 158.96 per share. | 30 Jul 2021 | 651 | 29,144 (0%) | 0% | 159.0 | 103,483 | Ordinary Shares |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2021 | 1,000 | 3,345 | - | - | Options to Buy Ordinary Shares | |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.45 per share. | 06 Jul 2021 | 1,000 | 73,859 (0%) | 0% | 31.5 | 31,450 | Ordinary Shares |
| Gabriel Leung | Director | Sale of securities on an exchange or to another person at price $ 183.54 per share. | 06 Jul 2021 | 1,000 | 72,859 (0%) | 0% | 183.5 | 183,540 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 137.12 per share. | 06 Jul 2021 | 66 | 150,080 (0%) | 0% | 137.1 | 9,050 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 137.12 per share. | 06 Jul 2021 | 90 | 29,144 (0%) | 0% | 137.1 | 12,341 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 137.12 per share. | 06 Jul 2021 | 118 | 8,302 (0%) | 0% | 137.1 | 16,180 | Ordinary Shares |
| Todd Christopher Longsworth | General Counsel | Grant, award, or other acquisition of securities at price $ 137.12 per share. | 06 Jul 2021 | 154 | 67,868 (0%) | 0% | 137.1 | 21,117 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 137.12 per share. | 06 Jul 2021 | 154 | 77,886 | - | 137.1 | 21,117 | Restricted Share Units |
| Uri Weinberg | Chief Science Officer | Grant, award, or other acquisition of securities at price $ 137.12 per share. | 06 Jul 2021 | 113 | 31,780 (0%) | 0% | 137.1 | 15,495 | Ordinary Shares |
| Ashley Cordova | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 137.12 per share. | 06 Jul 2021 | 100 | 35,993 (0%) | 0% | 137.1 | 13,712 | Ordinary Shares |
| Frank Leonard | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 137.12 per share. | 06 Jul 2021 | 154 | 90,199 (0%) | 0% | 137.1 | 21,117 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 215.00 per share. | 10 Jun 2021 | 23,540 | 77,732 (0%) | 0% | 215 | 5,061,100 | Ordinary Shares |
| Gabriel Leung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 814 | 72,859 | - | 0 | Restricted Stock Units | |
| Gabriel Leung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 1,499 | 1,499 | - | - | Options to Buy Ordinary Shares | |
| Sherilyn S. McCoy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 814 | 6,714 | - | 0 | Restricted Stock Units | |
| Sherilyn S. McCoy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 1,499 | 1,499 | - | - | Options to Buy Ordinary Shares | |
| David T. Hung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 1,499 | 1,499 | - | - | Options to Buy Ordinary Shares | |
| David T. Hung | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 814 | 6,714 | - | 0 | Restricted Stock Units | |
| Jeryl L. Hilleman | Director | Sale or transfer of securities back to the company at price $ 210.01 per share. | 09 Jun 2021 | 1,270 | 2,944 (0%) | 0% | 210.0 | 266,713 | Ordinary Shares |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 1,499 | 1,499 | - | - | Options to Buy Ordinary Shares | |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 814 | 4,214 | - | 0 | Restricted Stock Units | |
| W. Anthony Vernon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 814 | 161,944 | - | 0 | Restricted Stock Units | |
| W. Anthony Vernon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 1,499 | 1,499 | - | - | Options to Buy Ordinary Shares | |
| Martin J. Madden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 814 | 15,620 | - | 0 | Restricted Stock Units | |
| Martin J. Madden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2021 | 1,499 | 1,499 | - | - | Options to Buy Ordinary Shares | |
| Gabriel Leung | Director | Sale of securities on an exchange or to another person at price $ 204.55 per share. | 07 Jun 2021 | 1,000 | 72,045 (0%) | 0% | 204.6 | 204,550 | Ordinary Shares |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jun 2021 | 1,000 | 4,345 | - | - | Options to Buy Ordinary Shares | |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.45 per share. | 07 Jun 2021 | 1,000 | 73,045 (0%) | 0% | 31.5 | 31,450 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.56 per share. | 27 May 2021 | 1,833 | 30,887 (0%) | 0% | 47.6 | 87,177 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2021 | 1,833 | 7,332 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 27 May 2021 | 1,833 | 29,054 (0%) | 0% | 200 | 366,600 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 180.48 per share. | 12 May 2021 | 1,943 | 29,054 (0%) | 0% | 180.5 | 350,673 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.56 per share. | 10 May 2021 | 1,833 | 35,092 (0%) | 0% | 47.6 | 87,177 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2021 | 1,833 | 9,165 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 180.12 per share. | 10 May 2021 | 2,262 | 30,997 (0%) | 0% | 180.1 | 407,427 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 189.65 per share. | 10 May 2021 | 1,833 | 33,259 (0%) | 0% | 189.6 | 347,628 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Sale of securities on an exchange or to another person at price $ 189.65 per share. | 10 May 2021 | 1,804 | 31,667 (0%) | 0% | 189.7 | 342,129 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2021 | 3,846 | 3,845 | - | - | Options to Buy Ordinary Shares | |
| Uri Weinberg | Chief Science Officer | Sale of securities on an exchange or to another person at price $ 189.65 per share. | 10 May 2021 | 3,846 | 33,471 (0%) | 0% | 189.7 | 729,394 | Ordinary Shares |
| Uri Weinberg | Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.56 per share. | 10 May 2021 | 3,846 | 37,317 (0%) | 0% | 47.6 | 182,916 | Ordinary Shares |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.45 per share. | 05 May 2021 | 1,000 | 73,045 (0%) | 0% | 31.5 | 31,450 | Ordinary Shares |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 May 2021 | 1,000 | 5,345 | - | - | Options to Buy Ordinary Shares | |
| Gabriel Leung | Director | Sale of securities on an exchange or to another person at price $ 199.67 per share. | 05 May 2021 | 1,000 | 72,045 (0%) | 0% | 199.7 | 199,670 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 199.67 per share. | 05 May 2021 | 1,290 | 101,272 (0%) | 0% | 199.7 | 257,574 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2021 | 2,333 | 0 | - | - | Restricted Stock Units | |
| Pritesh Shah | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 204.10 per share. | 03 May 2021 | 2,333 | 103,605 (0%) | 0% | 204.1 | 476,165 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 200.86 per share. | 03 May 2021 | 1,043 | 102,562 (0%) | 0% | 200.9 | 209,493 | Ordinary Shares |
| Gabriel Leung | Director | Sale of securities on an exchange or to another person at price $ 198.01 per share. | 13 Apr 2021 | 3,500 | 74,545 (0%) | 0% | 198.0 | 693,035 | Ordinary Shares |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 6,000 | 6,345 | - | - | Options to Buy Ordinary Shares | |
| Gabriel Leung | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 31.45 per share. | 13 Apr 2021 | 6,000 | 78,045 (0%) | 0% | 31.5 | 188,700 | Ordinary Shares |
| Gabriel Leung | Director | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 13 Apr 2021 | 2,500 | 72,045 (0%) | 0% | 200 | 500,000 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 205.43 per share. | 13 Apr 2021 | 1,600 | 567,098 (0%) | 0% | 205.4 | 328,690 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 191.26 per share. | 13 Apr 2021 | 1,400 | 648,993 (0%) | 0% | 191.3 | 267,768 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 192.52 per share. | 13 Apr 2021 | 1,900 | 647,093 (0%) | 0% | 192.5 | 365,796 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 193.57 per share. | 13 Apr 2021 | 2,090 | 645,003 (0%) | 0% | 193.6 | 404,563 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 194.94 per share. | 13 Apr 2021 | 1,600 | 643,403 (0%) | 0% | 194.9 | 311,904 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 196.07 per share. | 13 Apr 2021 | 8,814 | 634,589 (0%) | 0% | 196.1 | 1,728,187 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 197.00 per share. | 13 Apr 2021 | 24,338 | 610,251 (0%) | 0% | 197.0 | 4,794,659 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 197.83 per share. | 13 Apr 2021 | 13,612 | 596,639 (0%) | 0% | 197.8 | 2,692,876 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 198.98 per share. | 13 Apr 2021 | 10,563 | 586,076 (0%) | 0% | 199.0 | 2,101,794 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 199.71 per share. | 13 Apr 2021 | 4,338 | 581,738 (0%) | 0% | 199.7 | 866,355 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 201.55 per share. | 13 Apr 2021 | 4,125 | 577,613 (0%) | 0% | 201.5 | 831,377 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 202.16 per share. | 13 Apr 2021 | 4,388 | 573,225 (0%) | 0% | 202.2 | 887,069 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 203.25 per share. | 13 Apr 2021 | 2,555 | 570,670 (0%) | 0% | 203.3 | 519,311 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 204.28 per share. | 13 Apr 2021 | 1,972 | 568,698 (0%) | 0% | 204.3 | 402,834 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 206.35 per share. | 13 Apr 2021 | 1,284 | 565,814 (0%) | 0% | 206.4 | 264,956 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 207.80 per share. | 13 Apr 2021 | 4,500 | 561,314 (0%) | 0% | 207.8 | 935,118 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 209.34 per share. | 13 Apr 2021 | 2,200 | 559,114 (0%) | 0% | 209.3 | 460,555 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 210.18 per share. | 13 Apr 2021 | 521 | 558,593 (0%) | 0% | 210.2 | 109,504 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 211.28 per share. | 13 Apr 2021 | 600 | 557,993 (0%) | 0% | 211.3 | 126,766 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 213.35 per share. | 13 Apr 2021 | 1,500 | 556,493 (0%) | 0% | 213.3 | 320,021 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 214.67 per share. | 13 Apr 2021 | 500 | 555,993 (0%) | 0% | 214.7 | 107,333 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 216.69 per share. | 13 Apr 2021 | 600 | 555,393 (0%) | 0% | 216.7 | 130,016 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 13 Apr 2021 | 1,833 | 33,259 (0%) | 0% | 200 | 366,600 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.56 per share. | 13 Apr 2021 | 1,833 | 35,092 (0%) | 0% | 47.6 | 87,177 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 3,474 | 19,404 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 651 | 3,904 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 1,833 | 10,998 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 13 Apr 2021 | 3,474 | 33,259 (0%) | 0% | 200 | 694,800 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 69.37 per share. | 13 Apr 2021 | 3,474 | 36,733 (0%) | 0% | 69.4 | 240,991 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 13 Apr 2021 | 651 | 33,259 (0%) | 0% | 200 | 130,200 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 83.30 per share. | 13 Apr 2021 | 651 | 33,910 (0%) | 0% | 83.3 | 54,228 | Ordinary Shares |
| Asaf Danziger | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 196.34 per share. | 13 Apr 2021 | 97,973 | 8,184 (0%) | 0% | 196.3 | 19,236,323 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Sale of securities on an exchange or to another person at price $ 134.12 per share. | 31 Mar 2021 | 7,928 | 650,393 (0%) | 0% | 134.1 | 1,063,303 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Exercise or conversion of derivative security received from the company (such as an option) at price $ 125.25 per share. | 31 Mar 2021 | 9,259 | 658,321 (0%) | 0% | 125.3 | 1,159,690 | Ordinary Shares |
| William F. Doyle | Director, Executive Chairman | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2021 | 9,259 | 0 | - | - | Restricted Stock Units | |
| Uri Weinberg | Chief Science Officer | Sale of securities on an exchange or to another person at price $ 140.00 per share. | 23 Mar 2021 | 2,835 | 33,471 (0%) | 0% | 140 | 396,900 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 130.81 per share. | 08 Mar 2021 | 3,004 | 153,684 | - | 130.8 | 392,941 | Restricted Share Units |
| Todd Christopher Longsworth | General Counsel | Sale of securities on an exchange or to another person at price $ 130.81 per share. | 08 Mar 2021 | 2,404 | 67,714 | - | 130.8 | 314,458 | Restricted Share Units |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 131.09 per share. | 08 Mar 2021 | 3,524 | 101,272 | - | 131.1 | 461,961 | Restricted Share Units |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 130.81 per share. | 08 Mar 2021 | 2,627 | 104,796 | - | 130.8 | 343,627 | Restricted Share Units |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 130.81 per share. | 08 Mar 2021 | 765 | 35,893 | - | 130.8 | 100,067 | Restricted Share Units |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 130.81 per share. | 08 Mar 2021 | 765 | 90,045 | - | 130.8 | 100,067 | Restricted Share Units |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 131.53 per share. | 05 Mar 2021 | 2,918 | 33,259 (0%) | 0% | 131.5 | 383,805 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 131.53 per share. | 05 Mar 2021 | 4,550 | 107,423 (0%) | 0% | 131.5 | 598,462 | Ordinary Shares |
| Pritesh Shah | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2021 | 13,987 | 0 | - | - | Options to Buy Ordinary Shares | |
| Pritesh Shah | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.15 per share. | 05 Mar 2021 | 13,987 | 111,973 (0%) | 0% | 7.1 | 100,007 | Ordinary Shares |
| Wilhelmus C. M. Groenhuysen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 137.55 per share. | 04 Mar 2021 | 3,854 | 156,688 | - | 137.6 | 530,133 | Restricted Share Units |
| Todd Christopher Longsworth | General Counsel | Sale of securities on an exchange or to another person at price $ 137.55 per share. | 04 Mar 2021 | 3,084 | 70,118 | - | 137.6 | 424,217 | Restricted Share Units |
| Ashley Cordova | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 137.55 per share. | 04 Mar 2021 | 567 | 37,568 | - | 137.6 | 77,993 | Restricted Share Units |
| Ashley Cordova | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2021 | 910 | 36,658 (0%) | 0% | 0 | Ordinary Shares | |
| Frank Leonard | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 137.55 per share. | 04 Mar 2021 | 567 | 90,810 | - | 137.6 | 77,993 | Restricted Share Units |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 150.78 per share. | 03 Mar 2021 | 3,475 | 38,065 (0%) | 0% | 150.8 | 523,961 | Ordinary Shares |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2021 | 3,475 | 22,878 | - | - | Options to Buy Ordinary Shares | |
| Ely Benaim | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 137.55 per share. | 03 Mar 2021 | 1,888 | 36,177 | - | 137.6 | 259,702 | Restricted Share Units |
| Ely Benaim | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 69.37 per share. | 03 Mar 2021 | 3,475 | 41,540 (0%) | 0% | 69.4 | 241,061 | Ordinary Shares |